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Statements Acknowledgments Work in our laboratories is supported by ERDF-cofinanced grants from the Ministry of Science and Innovation (BIO2012-33904 and BFU2011-22779)

Several non-oxidant apoptogenic agents such as tumor necrosis factor (Lee et al., 2002) and cycloheximide (Zhao et al., 2011) also elicit oxidative stress, indicating that ROS generation may be a conserved apoptotic event

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